Wada M, Yamamoto S, Ogata H, Sugita N, Kino T, Hayashi A
Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo.
Kekkaku. 1994 May;69(5):367-74.
It was reported that HIV-infected persons were at much higher risk to develop active tuberculosis than HIV-none-infected persons, about 10% of whom might develop active tuberculosis through their lives, almost identical percentage of HIV-infected persons had developed active tuberculosis annually. In Japan, 2838 HIV-infected persons including 621 AIDS-cases were reported by the end of June 1993. Oct. Ten HIV-infected cases of active mycobacteriosis have been reported in literatures or on scientific meeting. We experienced two tuberculosis cases with HIV-infection recently and will report herein.
A 23 years-old male student of Japanese-language school from Myammer. He was admitted to our hospital because of high fever and cough. His chest X-ray film taken on admission showed left hilar and mediastinal lymph nodes swelling, calcification of left hilar lymph node and infiltration in middle lung field. Sputum smear for acid fast bacilli was strongly positive. The cultured isolates were identified as Mycobacterium tuberculosis by DNA probe methods and were susceptibility tests were sensitive to all antituberculous drugs. Tuberculin skin reaction was negative. Laboratory data on admission: serum albumin level was 2.7 g/dl, A/G ratio was 0.75, CRP was 26.4 dg/ml, HBe antigen and antibody were positive, HIV antibody was positive by PA method and Western blot method, total lymphocyte count was 410/microliters, total T lymphocyte count was 303/microliters, total B lymphocyte count was 29/microliters, CD4+ T lymphocyte count was 37/microliters, CD8+ T lymphocyte count was 279/microliters, CD4+/CD8+ ratio was 0.1.(ABSTRACT TRUNCATED AT 250 WORDS)
据报道，与未感染艾滋病毒的人相比，感染艾滋病毒的人患活动性结核病的风险要高得多，未感染艾滋病毒的人一生中约有10%可能会患活动性结核病，而感染艾滋病毒的人每年患活动性结核病的比例几乎相同。在日本，截至1993年6月底，共报告了2838例感染艾滋病毒的人，其中包括621例艾滋病病例。10月。文献或科学会议上已报告了10例感染艾滋病毒的活动性分枝杆菌病病例。我们最近遇到了2例合并艾滋病毒感染的结核病病例，并在此报告。
一名23岁的来自缅甸的日语学校男学生。因高热和咳嗽入院。入院时拍摄的胸部X光片显示左肺门和纵隔淋巴结肿大、左肺门淋巴结钙化以及中肺野浸润。痰涂片抗酸杆菌呈强阳性。通过DNA探针方法将培养分离物鉴定为结核分枝杆菌，药敏试验显示对所有抗结核药物敏感。结核菌素皮肤反应为阴性。入院时实验室数据：血清白蛋白水平为2.7g/dl，A/G比值为0.75，CRP为26.4dg/ml，HBe抗原和抗体呈阳性，PA法和Western印迹法检测艾滋病毒抗体呈阳性，总淋巴细胞计数为410/微升，总T淋巴细胞计数为303/微升，总B淋巴细胞计数为29/微升，CD4 + T淋巴细胞计数为37/微升，CD8 + T淋巴细胞计数为279/微升，CD4 + /CD8 + 比值为0.1。（摘要截断于250字）
