Shkrob L O, Fedotov P A, Ermakova N G
Khirurgiia (Mosk). 1994 Mar(3):20-2.
The authors examined 48 patients with peritonitis (20 with the generalized and 28 with the localized form). The content of T-lymphocytes, theophylline-resistant and theophylline-sensitive T-lymphocytes, leukocyte chemotaxic activity, and the lymphocyte ATP content were studied. It was found that the state of the immune system in the early postoperative period allows the severity of the disease and its outcome to be prognosticated. A sharp decrease in the T-lymphocyte content and decrease of the amount of ATP in the lymphocytes in stable reduction of chemotaxic activity is an unfavorable prognostic sign. Introduction of indirect electrochemical oxidation with a sodium hypochlorite solution into the complex of intensive therapy produces, in addition to a marked detoxification effect, a stabilizing effect on metabolic processes in the lymphocytes and activates the cellular link of immunity. Combined immunocorrection with the agents tactivin and leukinferon possesses a high potential of an immunobiological effect and can be recommended for correction of severe secondary immunodeficiency in patients with generalized peritonitis.
作者检查了48例腹膜炎患者（20例为全身性腹膜炎，28例为局限性腹膜炎）。研究了T淋巴细胞、茶碱抵抗性和茶碱敏感性T淋巴细胞的含量、白细胞趋化活性以及淋巴细胞ATP含量。结果发现，术后早期免疫系统的状态可用于预测疾病的严重程度及其预后。T淋巴细胞含量急剧下降、淋巴细胞中ATP含量减少以及趋化活性持续降低是不良预后征象。在强化治疗方案中加入次氯酸钠溶液进行间接电化学氧化，除了具有显著的解毒作用外，还对淋巴细胞的代谢过程产生稳定作用，并激活免疫细胞环节。联合使用tactivin和白细胞干扰素进行免疫纠正具有很高的免疫生物学效应潜力，可推荐用于纠正全身性腹膜炎患者严重的继发性免疫缺陷。
