Diachuk I A, Benedikt V V
Khirurgiia (Mosk). 1994 Mar(3):22-4.
Experiments were conducted on albino rats to study lipid peroxidation (LPO) in muscle homogenates of the small intestine in peritonitis of various duration. LPO increased most significantly in 24-hour peritonitis. There was no statistically significant difference between the LPO values two days later and those of 24-hour peritonitis. With the use of the antioxidant alpha-tocopherol with essential 12 hours after the development of peritonitis no significant changes occurred in the LPO values. In 24-hour peritonitis LPO was initiated but it was less pronounced. alpha-Tocopherol acetate and essential were included in the complex of therapeutic measures in 20 patients. They were administered before and 3-4 days after the operation. As a result the motor-evacuation function of the gastrointestinal tract was restored in a shorter time. The postoperative period took a favorable course, and the duration of in-hospital treatment reduced by 2-3 days on the average.
对白化大鼠进行实验，以研究不同病程腹膜炎中小肠肌肉匀浆中的脂质过氧化（LPO）情况。LPO在24小时腹膜炎时增加最为显著。两天后的LPO值与24小时腹膜炎时的LPO值之间无统计学显著差异。在腹膜炎发生后12小时内使用抗氧化剂α-生育酚，LPO值无显著变化。在24小时腹膜炎中LPO开始出现，但不那么明显。20例患者的治疗措施组合中包括α-生育酚醋酸酯并必不可少。在手术前及手术后3 - 4天给药。结果，胃肠道的运动排空功能在更短时间内恢复。术后病程顺利，平均住院治疗时间缩短2 - 3天。
