[The role of photomodification, prevented by lipid peroxidation inhibitors, in the therapeutic effect of UV-irradiated blood in peritonitis in rats].

The blood of healthy animals was irradiated at 254 nm with incident dose 0.05 Einstein/m2 and was thirdly infused to the rats in volume 2 ml/Kg body weight. The infusion of irradiated blood decreased the lethality of rats. Maximal therapeutic action was observed at 7-9th day after peritonitis induction. This effect was completely inhibited by injection the cyclooxygenase inhibitors aspirin or indomethacin (but not lipid antioxidants BHT or alpha-tocopherol) into irradiated portion of blood before irradiation. The therapeutic effect of irradiated blood is due to cyclooxygenase activation by UV-radiation.