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氟尿嘧啶抗肿瘤及免疫抑制特性的比较研究

[Comparative study of antineoplastic and immunosuppressive properties of ftorafur].

作者信息

Nosova T A, Babichev V A, Uteshev B S

出版信息

Farmakol Toksikol. 1976 Sep-Oct;39(5):589-93.

PMID:800767
Abstract

In experiments staged on mice with transplantable leukemia L 1210 an immunodepressive and antineoplasic action of phthorafur was studied. Depending upon its dose phthorafur lowered the number of lymphoma colonies and antibody-forming cells in the spleen of the animals immunized with sheep erythrocytes. The maximal immunodepressive action was found to set in following administration of the agent in a dose of 500 mg/kg 24 and 48 hours after antigenic stimulation.

摘要

在用可移植性白血病L 1210小鼠进行的实验中,研究了呋喃氟脲嘧啶的免疫抑制和抗肿瘤作用。根据剂量不同,呋喃氟脲嘧啶可降低用绵羊红细胞免疫的动物脾脏中淋巴瘤集落和抗体形成细胞的数量。发现以500毫克/千克的剂量在抗原刺激后24小时和48小时给药后,免疫抑制作用达到最大。

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