金属硫蛋白I对线粒体氧消耗的影响。

Effect of metallothionein I on mitochondrial oxygen consumption.

作者信息

Simpkins C O, Zhao H L, Torrence C A

机构信息

University of Maryland School of Medicine, Department of Surgery, Baltimore.

出版信息

Life Sci. 1994;55(3):221-6. doi: 10.1016/0024-3205(94)00883-3.

DOI:10.1016/0024-3205(94)00883-3

PMID:8007764

Abstract

The effect of the stress-induced, cysteine-rich protein, metallothionein I (MT), on oxygen consumption by rat liver mitochondria was studied. Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT. The MT effect was concentration dependent. No evidence was found for the provision by MT of an alternate pathway to oxygen.

摘要

研究了应激诱导的富含半胱氨酸的蛋白质金属硫蛋白I（MT）对大鼠肝脏线粒体耗氧量的影响。使用克拉克型氧电极，我们发现MT增强了从琥珀酸到氧的电子传递，而MT抑制了ADP引发的氧消耗。MT的作用呈浓度依赖性。未发现MT为氧提供替代途径的证据。