樟脑对线粒体呼吸的影响。
The effect of camphor on mitochondrial respiration.
作者信息
Guilland-Cumming D F, Smith G J
出版信息
Experientia. 1982 Feb 15;38(2):236-7. doi: 10.1007/BF01945085.
PMID:7060709
Abstract
Camphor at less than 8 mumoles/mg protein reduced the rate of oxygen consumption by rat liver mitochondria. The effect occurs only with NAD+-linked substrates. Succinate linked respiration was inhibited but this appears to be caused by some conversion of succinate to malate. At higher levels, camphor increases oxygen consumption with succinate substrate, by uncoupling at site II.
摘要
低于8微摩尔/毫克蛋白质的樟脑降低了大鼠肝脏线粒体的耗氧率。这种作用仅在与NAD⁺相关的底物存在时发生。琥珀酸连接的呼吸作用受到抑制，但这似乎是由琥珀酸向苹果酸的某种转化引起的。在较高水平时，樟脑通过在II位点解偶联来增加以琥珀酸为底物时的耗氧量。
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