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单胎宫内死亡的双胎妊娠结局:与存活双胎妊娠的比较。

Outcome of twin pregnancies complicated by a single intrauterine death: a comparison with viable twin pregnancies.

作者信息

Kilby M D, Govind A, O'Brien P M

机构信息

Academic Department of Obstetrics, Keele University, North Staffordshire, United Kingdom.

出版信息

Obstet Gynecol. 1994 Jul;84(1):107-9.

PMID:8008302
Abstract

OBJECTIVE

To examine the perinatal and maternal outcomes in twin pregnancies when a single intrauterine death occurs.

METHODS

This was a retrospective, observational study. Comparison was made to viable twin pregnancies.

RESULTS

Of a total 34,804 live deliveries, 342 were documented as twin births at a gestation of greater than 20 weeks (incidence 0.98%). Of the twin pregnancies over this period, 20 (5.85%) were complicated by a single intrauterine death. There was an increase in the incidence of congenital structural abnormalities among those twins dying in utero as compared to uneventful twin pregnancies (25 versus 0.3%; P < .001). A significant proportion of these twin pregnancies had monochorionic placentas (35 versus 9%; P < .001) and were admitted to special care units (70 versus 5.6%; P < .001) as compared to the normal twin sample. Maternal morbidity has previously been described as being increased. Although there was an increased risk of nonproteinuric and mild pregnancy-induced hypertension, no adverse maternal effects of conservative management were noted in this study.

CONCLUSION

The risk of a single fetal death in twin pregnancies is increased with a monochorionic placenta or a structural abnormality. Conservative management and regular surveillance seem advisable.

摘要

目的

研究单胎宫内死亡时双胎妊娠的围产期及母体结局。

方法

这是一项回顾性观察研究。与存活的双胎妊娠进行比较。

结果

在总共34804例活产中,342例记录为孕周大于20周的双胎分娩(发生率0.98%)。在此期间的双胎妊娠中,20例(5.85%)并发单胎宫内死亡。与正常双胎妊娠相比,宫内死亡双胎的先天性结构异常发生率增加(25%对0.3%;P <.001)。与正常双胎样本相比,这些双胎妊娠中有很大比例为单绒毛膜胎盘(35%对9%;P <.001),且入住特殊护理病房的比例更高(70%对5.6%;P <.001)。先前已描述母体发病率会增加。尽管非蛋白尿性和轻度妊娠高血压的风险增加,但本研究未发现保守治疗对母体有不良影响。

结论

单绒毛膜胎盘或结构异常会增加双胎妊娠中单胎胎儿死亡的风险。保守治疗和定期监测似乎是可取的。

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