Kearns J Y, Hurd H, Pullin A S
Department of Biological Sciences, Keele University, Staffordshire, UK.
Parasitology. 1994 May;108 ( Pt 4):473-8. doi: 10.1017/s0031182000076034.
The metamorphosis of oncospheres of the rat tapeworm, Hymenolepis diminuta, to mature metacestodes induces several pathophysiological effects in the intermediate host, Tenebrio molitor (Coleoptera). Previous investigations have failed to elucidate the mechanism responsible for changes in the host reproductive physiology and behaviour. This work forms part of an assessment of the degree to which nutrient resource management may be involved in these interactions. We report that developing metacestodes exert a pronounced effect upon host carbohydrate reserves and also alter circulating carbohydrate titres at some stages post-infection. Biochemical studies of fat body glycogen demonstrated a significant depletion of reserves as early as 3 days post-infection in males and 5 days post-infection in females. Gas chromatography revealed trehalose to be the predominant haemolymph carbohydrate, titres being significantly elevated in male beetles 5 and 9 days post-infection and in females 12 days post-infection. Metacestodes had no effect on glucose concentrations in male or female beetles.
大鼠绦虫微小膜壳绦虫的六钩蚴发育为成熟的中绦期幼虫会在中间宿主黄粉虫（鞘翅目）中引发多种病理生理效应。以往的研究未能阐明导致宿主生殖生理和行为变化的机制。这项工作是对营养资源管理在这些相互作用中所涉及程度评估的一部分。我们报告称，发育中的中绦期幼虫对宿主碳水化合物储备有显著影响，并且在感染后的某些阶段还会改变循环中的碳水化合物水平。对脂肪体糖原的生化研究表明，早在感染后3天雄性黄粉虫和感染后5天雌性黄粉虫的糖原储备就显著减少。气相色谱分析显示海藻糖是血淋巴中主要的碳水化合物，感染后5天和9天雄性甲虫以及感染后12天雌性甲虫的海藻糖水平显著升高。中绦期幼虫对雄性或雌性甲虫的葡萄糖浓度没有影响。
