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在营养不良儿童中用山羊奶替代牛奶:一项随机双盲临床试验。

Goat's milk as a substitute for cow's milk in undernourished children: a randomized double-blind clinical trial.

作者信息

Razafindrakoto O, Ravelomanana N, Rasolofo A, Rakotoarimanana R D, Gourgue P, Coquin P, Briend A, Desjeux J F

机构信息

Service de Pédiatrie, Hôpital Befelatanana, Antananarivo, Madagascar.

出版信息

Pediatrics. 1994 Jul;94(1):65-9.

PMID:8008540
Abstract

OBJECTIVE

This paper compares the effects of goat's milk and cow's milk on weight gain and fat absorption, in children with overt malnutrition.

METHODS

Thirty hospitalized malnourished children aged from 1 to 5 years were included in a randomized double-blind trial. The children were fed either goat or cow's milk with a randomized will defined composition, added with vegetable oil, sugar, vitamins and minerals o achieve 1,000 kcal/liter. Children were offered 100 kcal/kg on the first day, with a regular daily increase in energy intake thereafter that reached 200 kcal/kg per day on the tenth day.

RESULTS

Both groups of children had the same degree of malnutrition on inclusion. The mean weight-for-height Z score was -1.7 in both groups. One death with candidiasis occurred in the goat's milk group. Weight gain was similar in both groups: 8.5 g/kg/day (SE = 1.37) with goat's milk and 7.8 (SE = 1.9) with cow's milk. There was no significant difference in HEM intake: 157 ml/kg/day (SE = 4), vs 162 (SE = 4) for goat and cow's milk, respectively. Fat absorption coefficients on the 15th day of treatment were also similar in both groups.

CONCLUSION

These results suggest that goat's milk has a nutritional value similar to that of cow's milk and could be used as an alternative to cow's milk for rehabilitating undernourished children.

摘要

目的

本文比较了山羊奶和牛奶对明显营养不良儿童体重增加和脂肪吸收的影响。

方法

30名年龄在1至5岁的住院营养不良儿童被纳入一项随机双盲试验。给这些儿童喂食随机确定成分的山羊奶或牛奶,添加植物油、糖、维生素和矿物质,使其达到每升1000千卡。第一天给儿童提供100千卡/千克的能量,此后每天能量摄入量有规律地增加,到第十天达到200千卡/千克/天。

结果

两组儿童纳入时营养不良程度相同。两组儿童身高别体重的平均Z评分均为-1.7。山羊奶组发生1例念珠菌病死亡。两组体重增加情况相似:山羊奶组为8.5克/千克/天(标准误=1.37),牛奶组为7.8(标准误=1.9)。两组的热卡摄入量无显著差异:山羊奶组为157毫升/千克/天(标准误=4),牛奶组为162(标准误=4)。治疗第15天的脂肪吸收系数在两组中也相似。

结论

这些结果表明,山羊奶具有与牛奶相似的营养价值,可作为牛奶的替代品用于营养不良儿童的康复治疗。

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