Jay V, Parkinson D, Becker L, Chan F W
Department of Pathology, Hospital for Sick Children-University of Toronto, Ontario, Canada.
Pediatr Pathol. 1994 Mar-Apr;14(2):253-76. doi: 10.3109/15513819409024259.
We present cell kinetic data including Ki-67 quantitation and flow cytometry on 117 pediatric brain/spinal cord tumors and review the literature. Although, in general, these proliferation indices are in agreement with the histologic grade, they are useful in prognostication in some instances when the histological features of malignancy are equivocal. Specific examples in which flow cytometry may prove particularly useful in this context are childhood ependymomas, which do not show frank anaplasia but have cellular foci with focal increase in mitoses, and choroid plexus neoplasms, where elevated S phase fractions have been associated with an adverse outcome. Thus Ki-67 quantitation and flow cytometry not only serve as useful adjuncts to conventional histologic grading but also in specific instances may provide new information on tumor prognosis.
我们展示了117例儿童脑/脊髓肿瘤的细胞动力学数据，包括Ki-67定量分析和流式细胞术，并对文献进行了综述。虽然一般来说，这些增殖指数与组织学分级一致，但在某些情况下，当恶性肿瘤的组织学特征不明确时，它们在预后判断中很有用。在这种情况下，流式细胞术可能特别有用的具体例子是儿童室管膜瘤，其没有明显的间变，但有细胞灶且有局灶性有丝分裂增加，以及脉络丛肿瘤，其中S期比例升高与不良预后相关。因此，Ki-67定量分析和流式细胞术不仅是传统组织学分级的有用辅助手段，而且在特定情况下可能提供有关肿瘤预后的新信息。
