[系统性红斑狼疮的免疫遗传学：II类HLA分子与T淋巴细胞抗原受体胚系基因之间的适配性有利于多种抗体的产生]
[Immunogenetics of systemic lupus: adequacy between HLA molecules class II and the germinal genes of antigen receptor of T-lymphocytes favours the production of various antibodies].
作者信息
Youinou P, Guillevin L, Semana G, Jouquan J, Muller S, Piette J C
机构信息
Laboratoire d'immunologie, CHU Morvan, Brest.
出版信息
Rev Med Interne. 1993;14(10):979. doi: 10.1016/s0248-8663(05)80097-9.
PMID:8009072
Abstract
The study of 30 patients with systemic lupus and of 153 relatives failed to show any differences in HLA and TCR beta haplotype frequencies between patients and relatives. A significant interaction between TCR V beta and HLA-DR/DQ genes in the response to the peptide U1-RNP A 35-58 was demonstrated.
摘要
对30例系统性红斑狼疮患者及其153名亲属的研究未能显示患者与亲属之间在HLA和TCRβ单倍型频率上存在任何差异。研究证明，在对肽U1-RNP A 35-58的反应中，TCR Vβ与HLA-DR/DQ基因之间存在显著的相互作用。
Zotero 插件