Maréchaud R, Humbert C, Bonneau F, Saint-André J P, Bataille B, Fieuzal S, Prono C, Vandermarcq P
Service de médecine interne, endocrinologie, hôpital Jean Bernard, Poitiers.
Rev Med Interne. 1993;14(10):989. doi: 10.1016/s0248-8663(05)80107-9.
We report 6 cases of corticotroph macroadenomas which show heterogeneity of clinical and biological features (from Cushing's syndrome to silent adenoma) and heterogeneity of immunocytochemical staining. One patient reported on had skin hyperpigmentation and ACTH hypersecretion without clear abnormal adrenocortical function; we believe that this patient's plasma contained ACTH with very low bioactivity.
我们报告了6例促肾上腺皮质激素细胞大腺瘤，这些肿瘤表现出临床和生物学特征的异质性（从库欣综合征到无功能腺瘤）以及免疫细胞化学染色的异质性。报道的1例患者有皮肤色素沉着和促肾上腺皮质激素分泌过多，但肾上腺皮质功能无明显异常；我们认为该患者血浆中促肾上腺皮质激素的生物活性非常低。
