Lloyd R V, Chandler W F, McKeever P E, Schteingart D E
Am J Surg Pathol. 1986 Sep;10(9):618-26. doi: 10.1097/00000478-198609000-00004.
The immunohistochemical characterization of 92 surgically resected abnormal pituitaries showed 24 cases with ACTH immunoreactivity. These included two cases of nodular hyperplasias, 20 functional adenomas, and two silent corticotropic adenomas. Both patients with nodular hyperplasia and 19 patients with functional adenomas had Cushing's disease, while one patient with a functional adenoma had Nelson's syndrome. The two silent corticotropic adenomas were not associated with Cushing's disease, although both patients had slightly elevated serum prolactin levels. The tumors, which were stained for beta-endorphin (12 cases) and alpha and beta-MSH (five cases) were all positive for these peptides. These results show that immunohistochemical staining is indispensable in the diagnosis of nodular hyperplasia and silent corticotropic adenomas and that it is extremely helpful in confirming the diagnosis of ACTH-producing adenomas.
对92例手术切除的异常垂体进行免疫组化特征分析，结果显示24例具有促肾上腺皮质激素（ACTH）免疫反应性。其中包括2例结节性增生、20例功能性腺瘤和2例无功能促肾上腺皮质激素腺瘤。结节性增生患者和19例功能性腺瘤患者均患有库欣病，而1例功能性腺瘤患者患有尼尔森综合征。2例无功能促肾上腺皮质激素腺瘤与库欣病无关，尽管这2例患者的血清催乳素水平均略有升高。对β-内啡肽染色的肿瘤（12例）以及对α-促黑素和β-促黑素染色的肿瘤（5例）对这些肽均呈阳性反应。这些结果表明，免疫组化染色在结节性增生和无功能促肾上腺皮质激素腺瘤的诊断中不可或缺，并且在确诊产生ACTH的腺瘤方面极有帮助。
