Lidén S, Beckman L, Cedergren B, Göransson K, Nyquist H
Acta Derm Venereol Suppl (Stockh). 1978;58(79):53-6.
The relationship between HLA factors and allergic contact dermatitis was examined in a series of 149 patients with unequivocal positive reactions to one or several allergens on epicutaneous testing. Nine statistically significant associations involving 6 different HLA antigens and 6 different allergens were found. Four allergens (chromium, formalin, balsam of Peru and wool alcohol) were positively associated with the B7 antigen. Furthermore chromium allergy was associated with A3, formalin allergy with A2 (negative association) and A9, nickel allergy with B8 and colophony allergy with B27. The B7 antigen and the combination A3+B7 showed significant regressions on number of allergies. The results fit the hypothesis that some HLA factors (like B7) may predispose for multiple contact allergy and others for allergen specific reactions.
对149例经皮试对一种或几种过敏原明确呈阳性反应的患者进行了研究，以探讨HLA因子与过敏性接触性皮炎之间的关系。发现了9种具有统计学意义的关联，涉及6种不同的HLA抗原和6种不同的过敏原。四种过敏原（铬、福尔马林、秘鲁香脂和羊毛醇）与B7抗原呈正相关。此外，铬过敏与A3相关，福尔马林过敏与A2（负相关）和A9相关，镍过敏与B8相关，松香过敏与B27相关。B7抗原以及A3 + B7组合与过敏数量呈显著回归关系。结果符合以下假设：某些HLA因子（如B7）可能易引发多种接触性过敏，而其他因子则易引发过敏原特异性反应。
