Karvonen J, Silvennoinen-Kassinen S, Ilonen J, Jakkula H, Tiilikainen A
Ann Clin Res. 1984;16(4):211-2.
HLA-A, B and C antigens were determined in 38 and HLA-DR and MT antigens in 30 patients with nickel allergy. The prevalence of B12 was increased (p less than 0.007) and that of DR1 decreased (p less than 0.02). Although these deviations are statistically significant, it is more likely that they are only coincidental and not an evidence of a real association between HLA and nickel allergy. This data, as in earlier reports does not indicate significant associations between HLA antigens and nickel allergy.
对38例镍过敏患者测定了HLA - A、B和C抗原，对30例患者测定了HLA - DR和MT抗原。发现B12的发生率增加（p<0.007），而DR1的发生率降低（p<0.02）。尽管这些偏差具有统计学意义，但更有可能只是巧合，并非HLA与镍过敏之间存在真正关联的证据。与早期报告一样，这些数据并未表明HLA抗原与镍过敏之间存在显著关联。
