Sauer T, Naess O, Kåresen R, Jacobsen U, Amlie E, Haug E
Patologisk anatomisk avdeling, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1994 Apr 10;114(9):1053-5.
Several methods exist for determining oestrogen receptor status in breast carcinomas. Biochemical methods have been widely used for many years, but recently immunocytochemical methods have become available. We have compared the outcome of the biochemical and immunocytological analysis in 274 breast cancer patients. Fine needle aspirates from all the patients were investigated immunocytologically and 214 tumours were positive (78%) and 60 negative (22%). Biochemical data were available in 155 patients, and the concordance between the two methods was 88%. Most of the 119 carcinomas (43%) that were only investigated cytologically were too small to allow both histological and biochemical analysis. A minority of patients were not operated on because of high age, and/or impaired health, or because the tumour was inoperable. In our opinion, biochemical and immunocytological methods are equally sensitive and specific in detecting oestrogen receptor in breast tumour tissue. In fine needle aspirates there is the additional advantage of morphological assessment of malignant nuclei and the possibility of obtaining material from small lesions.
有多种方法可用于确定乳腺癌中的雌激素受体状态。生化方法多年来一直被广泛使用，但最近免疫细胞化学方法也已可用。我们比较了274例乳腺癌患者生化分析和免疫细胞学分析的结果。对所有患者的细针穿刺抽吸物进行了免疫细胞学检查，214例肿瘤呈阳性（78%），60例呈阴性（22%）。155例患者有生化数据，两种方法之间的一致性为88%。仅进行细胞学检查的119例癌（43%）中的大多数太小，无法同时进行组织学和生化分析。少数患者因年龄较大、健康状况受损或肿瘤无法手术而未接受手术。我们认为，生化方法和免疫细胞学方法在检测乳腺肿瘤组织中的雌激素受体方面同样敏感和特异。在细针穿刺抽吸物中，还有对恶性细胞核进行形态学评估以及从小病变获取材料的额外优势。
