[阿尔茨海默病的临床-断层扫描相关性]

[The clinico-tomographic correlates in Alzheimer's disease].

作者信息

Selezneva N D, Kolykhanov I V, Nikiforuk N M, Savvateva N Iu, Ermilova E N, Vavilov S B, Gavrilova S I

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1994;94(1):65-9.

Abstract

Brain computed tomographic scans of 43 patients with Alzheimer's disease (moderate and severe dementia) were compared to those of age-matched normal subjects (30 controls). Computed tomographic analysis included some linear and volume ventricular measurements. These indices correlated with relevant psychopathological and psychometric findings. Linear measurements of the ventricular size and the degree of cortical, central atrophy were significantly greater in patients with Alzheimer's disease than in the control group. In line with the disease progression and its development from moderate to severe dementia the degree of brain structural changes increased with the predominance of cortical atrophy in parietal lobes and central atrophy in mediobasal parts of the temporal lobes.

摘要

对43例阿尔茨海默病（中度和重度痴呆）患者的脑部计算机断层扫描结果与年龄匹配的正常受试者（30名对照）的扫描结果进行了比较。计算机断层扫描分析包括一些线性和脑室容积测量。这些指标与相关的精神病理学和心理测量结果相关。阿尔茨海默病患者的脑室大小线性测量值以及皮质、中央萎缩程度显著高于对照组。随着疾病从中度发展到重度痴呆，脑结构变化程度增加，以顶叶皮质萎缩和颞叶中基部中央萎缩为主。