Drayer B P, Heyman A, Wilkinson W, Barrett L, Weinberg T
Ann Neurol. 1985 Apr;17(4):407-10. doi: 10.1002/ana.410170420.
Brain computed tomographic scans of 60 patients with early-onset Alzheimer's disease (mean age, 60.7 years) were compared with those of age- and sex-matched control subjects. Computed tomographic analysis included standard ventricular measurements as well as subjective ratings of ventricular and sulcal size. These indices were correlated with the results of a battery of neuropsychological tests and electroencephalographic findings. Linear measurements of ventricular size were significantly greater in the patients with Alzheimer's disease than in the age-matched control group (p less than 0.0005). Using subjective appraisal of ventricular and sulcal size, the neuroradiologist noted abnormalities significantly more often in patients than in controls (p less than 0.0005). Linear measurements of ventricular size correlated significantly (p less than 0.05) with the severity of aphasia and dementia and the presence of electroencephalographic abnormalities. There was, however, no correlation between the subjective judgment of cortical atrophy and the degree of impairment as measured by neuropsychological tests. The findings in this study demonstrate the usefulness of computed tomographic imaging in Alzheimer's disease of early onset.
对60例早发性阿尔茨海默病患者（平均年龄60.7岁）的脑部计算机断层扫描结果与年龄和性别匹配的对照受试者进行了比较。计算机断层扫描分析包括标准脑室测量以及对脑室和脑沟大小的主观评分。这些指标与一系列神经心理学测试结果和脑电图检查结果相关。阿尔茨海默病患者的脑室大小线性测量值显著大于年龄匹配的对照组（p<0.0005）。通过对脑室和脑沟大小的主观评估，神经放射科医生发现患者出现异常的频率显著高于对照组（p<0.0005）。脑室大小的线性测量值与失语症和痴呆的严重程度以及脑电图异常的存在显著相关（p<0.05）。然而，皮质萎缩的主观判断与神经心理学测试所测量的损伤程度之间没有相关性。本研究结果表明计算机断层扫描成像在早发性阿尔茨海默病中具有实用性。
