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1-氨基-6-氟-1,4-二氢-4-氧代-7-（取代）哌嗪基-3-喹啉羧酸及其衍生物的合成与抗菌活性

[Synthesis and antibacterial activities of 1-amino-6-fluoro-1,4-dihydro-4-oxo-7-(substituted) piperazinyl-3-quinolinecarboxylic acids and their derivatives].

作者信息

Xin T, Ding J, Zhang X P

机构信息

Shanghai Institute of Pharmaceutical Industry.

出版信息

Yao Xue Xue Bao. 1993;28(11):865-9.

PMID:8010004
Abstract

The title compounds 6-24 were obtained by the reaction of 5 with corresponding benzaldehydes. 5 was prepared with ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylate by hydrolysis, amination and condensation with piperazine. Anti-bacterial activities of 5-24 were tested in vitro.

摘要

标题化合物6 - 24是通过5与相应的苯甲醛反应得到的。5是由7 - 氯 - 6 - 氟 - 1,4 - 二氢 - 4 - 氧代 - 3 - 喹啉羧酸乙酯经水解、胺化并与哌嗪缩合制备而成。对5 - 24的抗菌活性进行了体外测试。

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