1-乙基-6-氟-1,4-二氢-4-氧代-7-(4-芳酰硫代氨基甲酰基-1-哌嗪基)-3-喹啉羧酸的合成及其抗菌作用
[Synthesis and antibacterial action of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroylthiocarbamoyl-1-piperaziny l)-3-quinoline carboxylic acids].
作者信息
Jia X S, Wang Y L, He F S, Shan Y F, Li Y F, Wang Y
机构信息
Department of Chemistry, Henan Normal University, Xinxiang.
出版信息
Yao Xue Xue Bao. 1993;28(6):477-80.
PMID:8249608
Abstract
Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl-1-piperazinyl)-3- quinoline carboxylic acids were prepared. Their structures were characterized by elemental analysis, IR, HNMR and MS spectra. Preliminary pharmacological tests indicated that some of compounds Ia-m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 micrograms/ml.
摘要
制备了13种新的1-乙基-6-氟-1,4-二氢-4-氧代-7-(4-芳酰基硫代氨基甲酰基-1-哌嗪基)-3-喹啉羧酸。通过元素分析、红外光谱、核磁共振氢谱和质谱对其结构进行了表征。初步药理试验表明，部分化合物Ia - m在浓度为100微克/毫升时对大肠杆菌、枯草芽孢杆菌和变形杆菌具有较强的抑制活性。
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