Wang H, Peng R X
Department of Pharmacology, Hubei Medical University, Wuhan, China.
Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):81-3.
Sodium ferulate (SF) is one of the effective components of Angelica sinensis Diels. Pretreatment with SF (100 mg.kg-1 ig, qd x 10 d) inhibited the activity of serum alanine aminotransferase, prevented the depletion of liver glycogen and glutathione, increased the liver homogenate and microsomal glutathione S-transferase activities, and reduced the malondialdehyde content, the membrane fluidity of liver microsome and the mitochondria in paracetamol (130 mg.kg-1, ip)-induced liver toxicity in mice. These results demonstrated the hepato-protective action of SF in mice.
阿魏酸钠（SF）是当归的有效成分之一。用阿魏酸钠（100毫克·千克-1，灌胃，每日一次，共10天）预处理可抑制血清丙氨酸转氨酶的活性，防止肝糖原和谷胱甘肽的消耗，增加肝匀浆和微粒体谷胱甘肽S-转移酶的活性，并降低丙二醛含量、肝微粒体膜流动性以及对乙酰氨基酚（130毫克·千克-1，腹腔注射）诱导的小鼠肝毒性中的线粒体损伤。这些结果证明了阿魏酸钠对小鼠的肝脏保护作用。
