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[中华眼镜蛇毒中131I-细胞毒素14在大鼠体内的分布]

[Distribution of 131I-cytotoxin 14 from Naja naja atra venom in rats].

作者信息

Guo M P, Wang Q C, Liu G F

机构信息

Laboratory of Snake Venom Research, Fujian Medical College, Fuzhou, China.

出版信息

Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):90-2.

PMID:8010097
Abstract

Cytotoxin 14 (CT14) from Naja naja atra venom was labelled with 131I by chloramine-T method and its tissue distribution was studied in rats. The highest concentration of the cytotoxin was found in kidney, 5979 dpm per mg weight, 14 times more than that of the control animals, at 0.5 h after i.v. injection and high concentrations were found in liver, spleen, pancreas, and adrenal. CT14 was also found in brain at 2 h after injection, 50 dpm per mg weight, 3 times more than that of the control.

摘要

用氯胺 - T法将中华眼镜蛇毒细胞毒素14(CT14)标记上131I,并在大鼠中研究其组织分布。静脉注射后0.5小时,在肾脏中发现细胞毒素的浓度最高,每毫克重量为5979 dpm,是对照动物的14倍,并且在肝脏、脾脏、胰腺和肾上腺中也发现了高浓度。注射后2小时,在脑中也发现了CT14,每毫克重量为50 dpm,是对照的3倍。

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