用[15O]H2O正电子发射断层扫描术测定颈内动脉球囊闭塞试验期间的脑血流量

[15O]H2O positron emission tomography determination of cerebral blood flow during balloon test occlusion of the internal carotid artery.

作者信息

Brunberg J A, Frey K A, Horton J A, Deveikis J P, Ross D A, Koeppe R A

机构信息

Department of Radiology, University of Michigan Hospital, Ann Arbor 48109-0030.

出版信息

AJNR Am J Neuroradiol. 1994 Apr;15(4):725-32.

PMID:8010276

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8334202/

Abstract

PURPOSE

To determine the utility of [15O]H2O positron emission tomography (PET) for the quantitative determination of cerebral blood flow in patients undergoing balloon test occlusion of the internal carotid artery.

METHODS

Twenty-two [15O]H2O PET cerebral blood flow studies were completed on 20 patients for whom temporary or permanent occlusion of the internal carotid artery was being considered because of skull base tumor or internal carotid artery aneurysm. In each study, cerebral blood flow was determined during temporary balloon internal carotid artery occlusion, and again after deflation and removal of the balloon from the internal carotid artery.

RESULTS

Patients were divided into three groups based on clinical and cerebral blood flow response to balloon test occlusion. Studies were classified as group I when associated with no clinical symptomatology and with a cerebral blood flow decrease of less than 10 mL/100 g per minute (16 of 22 patients); as group II when there was no clinical symptomatology and cerebral blood flow fell to 25 to 35 mL/100 g per minute on the occluded side (5 of 22); and as group III when the patient was clinically unable to tolerate test occlusion and had a cerebral blood flow of less than 20 mL/100 g per minute on the occluded side (1 of 22). Neurologic sequelae developed in none of the eight group I patients later undergoing permanent internal carotid artery occlusion. Cerebral infarction developed subsequently in the one group II patient who underwent internal carotid artery occlusion.

CONCLUSION

During internal carotid artery balloon test occlusion, [15O] H2O PET determination of cerebral blood flow allows rapid quantitative determination of cerebral blood flow throughout the entire brain, predicting the adequacy of collateral flow after permanent occlusion. All patients were able to tolerate the [15O]H2O PET cerebral blood flow determination, and there were no complications of the procedure.

摘要

目的

确定[15O]H2O正电子发射断层扫描（PET）在定量测定接受颈内动脉球囊闭塞试验患者脑血流量方面的效用。

方法

对20例因颅底肿瘤或颈内动脉动脉瘤而考虑进行颈内动脉临时或永久性闭塞的患者完成了22项[15O]H2O PET脑血流量研究。在每项研究中，在颈内动脉临时球囊闭塞期间测定脑血流量，并在球囊从颈内动脉放气和移除后再次测定。

结果

根据对球囊闭塞试验的临床和脑血流量反应，将患者分为三组。当与无临床症状且脑血流量每分钟减少少于10 mL/100 g相关时（22例患者中的16例），研究被分类为I组；当无临床症状且闭塞侧脑血流量降至每分钟25至35 mL/100 g时（22例中的5例），为II组；当患者临床上无法耐受试验闭塞且闭塞侧脑血流量少于每分钟20 mL/100 g时（22例中的1例），为III组。后来接受颈内动脉永久性闭塞的8例I组患者中无一发生神经后遗症。随后，接受颈内动脉闭塞的1例II组患者发生了脑梗死。