Nierenberg A A, Adler L A, Peselow E, Zornberg G, Rosenthal M
Psychiatry Service, New York Department of Veterans Affairs Medical Center.
Am J Psychiatry. 1994 Jul;151(7):1069-72. doi: 10.1176/ajp.151.7.1069.
The authors investigated trazodone as a hypnotic for depressed patients who had persistent, exacerbated, or new insomnia while taking either fluoxetine or bupropion.
Seventeen depressed patients who had insomnia while taking fluoxetine or bupropion were given either trazodone or placebo in a double-blind crossover trial. Sleep was assessed by self-report with the Pittsburgh Sleep Quality Index and the sleep items of the Yale-New Haven Hospital Depressive Symptom Inventory.
Improvement with trazodone, but not with placebo, was shown by the total Pittsburgh index scores and Yale-New Haven inventory total sleep scores and by the Pittsburgh index measures of sleep duration and Yale-New Haven inventory measures of early morning awakening, and there was a trend toward improvement in the Yale-New Haven inventory item regarding middle of the night awakenings. Subjective sleep quality and sleep latency also showed a trend toward improvement, but the Pittsburgh index measures of sleep efficiency and disturbances and the Yale-New Haven inventory item regarding difficulty falling asleep were unaffected by trazodone. One patient dropped out because of excessive daytime sedation with trazodone, and another dropped out because of nonresponse to placebo. Of the completers, 67% experienced overall improvement in sleep with trazodone according to a priori criteria, whereas only 13% experienced improvement with placebo.
Trazodone is an effective hypnotic for patients with antidepressant-associated insomnia.
作者研究了曲唑酮对在服用氟西汀或安非他酮时出现持续性、加重性或新发失眠的抑郁症患者的催眠作用。
在一项双盲交叉试验中，17名在服用氟西汀或安非他酮时伴有失眠的抑郁症患者被给予曲唑酮或安慰剂。通过匹兹堡睡眠质量指数的自我报告以及耶鲁 - 纽黑文医院抑郁症状量表中的睡眠项目来评估睡眠情况。
匹兹堡指数总分、耶鲁 - 纽黑文量表总睡眠得分、匹兹堡指数中的睡眠时间测量以及耶鲁 - 纽黑文量表中的清晨觉醒测量结果显示，曲唑酮组有改善，而安慰剂组无改善，并且在耶鲁 - 纽黑文量表中关于半夜觉醒的项目有改善趋势。主观睡眠质量和睡眠潜伏期也有改善趋势，但匹兹堡指数中的睡眠效率和干扰测量以及耶鲁 - 纽黑文量表中关于入睡困难的项目未受曲唑酮影响。一名患者因曲唑酮导致日间过度镇静而退出，另一名患者因对安慰剂无反应而退出。根据预先设定的标准，在完成试验的患者中，67%的患者使用曲唑酮后睡眠总体改善，而使用安慰剂的患者中只有13%有改善。
曲唑酮对伴有抗抑郁药相关失眠的患者是一种有效的催眠药物。
