Osawa M, Shingu K, Murakawa M, Adachi T, Kurata J, Seo N, Murayama T, Nakao S, Mori K
Department of Anesthesia, Kyoto University Hospital, Japan.
Anesth Analg. 1994 Jul;79(1):52-7. doi: 10.1213/00000539-199407000-00011.
We analyzed the effect of a new volatile anesthetic, sevoflurane (2%-5% in oxygen) on the electroencephalogram (EEG) of the neocortex, amygdala, and hippocampus, cortical somatosensory evoked potential (SEP), and brainstem reticular multiunit activity (R-MUA) in cats. Sevoflurane suppressed the background activity of the neocortex more than the amygdala and hippocampus. With increasing concentration of sevoflurane, the cortical EEG progressed from high-amplitude slow waves to a suppression-burst pattern, which was followed by an isoelectric pattern and then spikes with isoelectricity. The amplitude of the SEP was augmented and the R-MUA was suppressed by sevoflurane in a dose-related manner. Repetitive peripheral electrical stimulation induced generalized seizures at 5% sevoflurane in 2 of 13 cats. These results suggest that sevoflurane suppresses the background central nervous system electrical activities in a dose-related manner, leaving the reactive capabilities facilitated at deep anesthesia.
我们分析了一种新型挥发性麻醉剂七氟醚（在氧气中浓度为2%-5%）对猫的新皮质、杏仁核和海马体的脑电图（EEG）、皮质体感诱发电位（SEP）以及脑干网状多单位活动（R-MUA）的影响。七氟醚对新皮质背景活动的抑制作用比对杏仁核和海马体的抑制作用更强。随着七氟醚浓度的增加，皮质脑电图从高振幅慢波发展为抑制-爆发模式，随后是等电位模式，然后是伴有等电位的棘波。七氟醚以剂量相关的方式增强SEP的振幅并抑制R-MUA。在13只猫中，有2只在5%七氟醚浓度下，重复外周电刺激诱发了全身性癫痫发作。这些结果表明，七氟醚以剂量相关的方式抑制中枢神经系统的背景电活动，在深度麻醉时使反应能力增强。
