Utsumi J, Adachi T, Kurata J, Miyazaki Y, Shibata M, Murakawa M, Arai T, Mori K
Department of Anaesthesia, Kyoto University Hospital, Japan.
Br J Anaesth. 1998 May;80(5):628-33. doi: 10.1093/bja/80.5.628.
We have compared the effects of xenon and nitrous oxide on central nervous system (CNS) electrical activity during sevoflurane anaesthesia in cats by recording the electroencephalogram (EEG), multi-unit activity of the midbrain reticular formation (R-MUA) and somatosensory evoked potentials (SEP). Basal anaesthesia with 2% and 5% sevoflurane was used. With 2% sevoflurane, 70% xenon initially produced rhythmic slow waves which were followed by bursts of high-amplitude sharp waves interrupted by low amplitude slow waves on the EEG. Xenon induced an initial increase, followed by a decrease in R-MUA. Nitrous oxide 70% decreased the amplitude of the EEG activity which was associated with an increase in R-MUA. Xenon suppressed the amplitude of both the initial positive and negative deflections of the SEP to a greater extent than nitrous oxide. With 5% sevoflurane anaesthesia, both anaesthetics increased the frequency of spikes on the EEG and facilitated R-MUA. These findings indicate that xenon has a stimulatory action on CNS background activity and a suppressive action on CNS reactive capability which is more potent than that of nitrous oxide.
我们通过记录脑电图（EEG）、中脑网状结构的多单位活动（R-MUA）和体感诱发电位（SEP），比较了氙气和氧化亚氮对猫七氟醚麻醉期间中枢神经系统（CNS）电活动的影响。使用2%和5%的七氟醚进行基础麻醉。使用2%七氟醚时，70%的氙气最初产生有节律的慢波，随后脑电图上出现高振幅尖波爆发，并伴有低振幅慢波。氙气导致R-MUA先增加后减少。70%的氧化亚氮降低了脑电图活动的振幅，这与R-MUA增加有关。氙气比氧化亚氮更能抑制SEP初始正相和负相偏转的振幅。使用5%七氟醚麻醉时，两种麻醉剂均增加了脑电图上棘波的频率并促进了R-MUA。这些发现表明，氙气对中枢神经系统背景活动有刺激作用，对中枢神经系统反应能力有抑制作用，且比氧化亚氮更有效。
