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离子载体X537A诱导大鼠离体肥大细胞释放组胺的机制。II. 细胞体积增加与组胺释放之间的关系。

The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. II. The relationship between increase of cell volume and histamine release.

作者信息

Diamant B, Kazimierczak W, Patkar S A

出版信息

Agents Actions. 1978 Jun;8(4):315-23. doi: 10.1007/BF01968610.

DOI:10.1007/BF01968610
PMID:80105
Abstract

The ionophore X537A induced swelling of isolated rat mast cells parallel to histamine release. Both actions were depressed by extracellular calcium and BSA, temperatures below 37 degrees C, NEM, PMSF, and TTX, and were enhanced by high potassium and pretreatment of the cells with ATP. DSCG, theophylline, and DFP enhanced the histamine release noted after 10 min of incubation without influencing the swelling action of X537A. The swelling action could not be separated from histamine release and it is suggested that it might be inherent in the mechanism of secretion induced by X537A. The present results further distinguish histamine release induced by the two ionophores X537A and A23187.

摘要

离子载体X537A可引起离体大鼠肥大细胞肿胀，且与组胺释放平行。这两种作用均受到细胞外钙、牛血清白蛋白、低于37摄氏度的温度、N-乙基马来酰胺（NEM）、苯甲基磺酰氟（PMSF）和河豚毒素（TTX）的抑制，而高钾以及用三磷酸腺苷（ATP）对细胞进行预处理则可增强这两种作用。二丁酰环磷腺苷钙（DSCG）、茶碱和二异丙基氟磷酸（DFP）可增强孵育10分钟后观察到的组胺释放，但不影响X537A的肿胀作用。肿胀作用与组胺释放无法分离，提示其可能是X537A诱导的分泌机制所固有的。目前的结果进一步区分了由两种离子载体X537A和A23187诱导的组胺释放。

相似文献

1
The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. II. The relationship between increase of cell volume and histamine release.离子载体X537A诱导大鼠离体肥大细胞释放组胺的机制。II. 细胞体积增加与组胺释放之间的关系。
Agents Actions. 1978 Jun;8(4):315-23. doi: 10.1007/BF01968610.
2
The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. I. Significance of monovalent cations, calcium, metabolic energy and temperature.离子载体X537A诱导大鼠离体肥大细胞释放组胺的机制。I. 单价阳离子、钙、代谢能量和温度的意义。
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Swelling as a possible mechanism of action of X537A to release histamine from rat mast cells [proceedings].肿胀作为X537A从大鼠肥大细胞释放组胺的一种可能作用机制[会议论文集]
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Mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells.离子载体X537A诱导大鼠离体肥大细胞释放组胺的机制。
Int Arch Allergy Appl Immunol. 1978;56(2):179-87. doi: 10.1159/000232021.
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Jpn J Pharmacol. 1984 Jan;34(1):9-14. doi: 10.1254/jjp.34.9.
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Mechanism of histamine release from rat mast cells induced by the ionophore A23187: effects of calcium and temperature.离子载体A23187诱导大鼠肥大细胞释放组胺的机制：钙和温度的影响
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Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium.在无细胞外钙的情况下，离子载体A23187诱导大鼠肥大细胞释放组胺。
Eur J Pharmacol. 1980 Apr 4;62(4):329-34. doi: 10.1016/0014-2999(80)90100-4.

引用本文的文献

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The influence of hypertonicity on histamine release from isolated rat mast cells.高渗对离体大鼠肥大细胞组胺释放的影响。
Agents Actions. 1980 Apr;10(1 Pt 2):140-4. doi: 10.1007/BF02024197.
2
Atropine and hexamethonium-sensitive, Ca/K-modulated, reversible swelling of mast cells in rat mesentery, due to feeding or exposure to carbachol.由于喂食或接触卡巴胆碱，大鼠肠系膜中肥大细胞出现对阿托品和六甲铵敏感、钙/钾调节的可逆性肿胀。
Agents Actions. 1988 Aug;25(1-2):4-10. doi: 10.1007/BF01969086.
3
Valinomycin, a degranulating agent in rat mast cells which inhibits calcium-uptake.

本文引用的文献

1
Isolation and characterization of a noncytotoxic mast-cell activator from cobra venom.从眼镜蛇毒液中分离和鉴定一种非细胞毒性的肥大细胞激活剂。
Inflammation. 1975 Mar;1(1):103-15. doi: 10.1007/BF00918063.
2
Storage of histamine in mast cells. Evidence for an ionic binding of histamine to protein carboxyls in the granule heparin-protein complex.组胺在肥大细胞中的储存。组胺与颗粒肝素-蛋白质复合物中蛋白质羧基离子结合的证据。
Acta Physiol Scand Suppl. 1970;336:1-26.
3
Cation complexation by valinomycin- and nigericin-type inophores registered by the fluorescence signal of Tl+.
缬氨霉素，一种可使大鼠肥大细胞脱粒的物质，它能抑制钙摄取。
Agents Actions. 1987 Dec;22(3-4):189-96. doi: 10.1007/BF02009045.
通过铊离子荧光信号记录的缬氨霉素和尼日利亚菌素型离子载体的阳离子络合作用。
Biochemistry. 1974 Jul 16;13(15):3052-7. doi: 10.1021/bi00712a009.
4
Properties of ionophores with broad range cation selectivity.具有广泛阳离子选择性的离子载体的特性。
Fed Proc. 1973 Jun;32(6):1698-703.
5
Membrane fusion during mast cell secretion.肥大细胞分泌过程中的膜融合。
J Cell Biol. 1973 Apr;57(1):252-9. doi: 10.1083/jcb.57.1.252.
6
Electron microscope evidence of calcium-induced exocytosis in mast cells treated with 48-80 or the ionophores A-23187 and X-537A.用48 - 80或离子载体A - 23187和X - 537A处理的肥大细胞中钙诱导胞吐作用的电子显微镜证据。
J Cell Biol. 1974 Aug;62(2):519-26. doi: 10.1083/jcb.62.2.519.
7
Calcium-induced extrusion of secretory granules (exocytosis) in mast cells exposed to 48-80 or the ionophores A-23187 and X-537A.在暴露于48 - 80或离子载体A - 23187和X - 537A的肥大细胞中，钙诱导分泌颗粒的外排（胞吐作用）。
Proc Natl Acad Sci U S A. 1974 Feb;71(2):408-12. doi: 10.1073/pnas.71.2.408.
8
Histamine release from isolated rat peritoneal mast cells induced by adenosine-5'-triphosphate.三磷酸腺苷诱导大鼠腹膜肥大细胞释放组胺。
Acta Physiol Scand. 1967 Dec;71(4):291-302. doi: 10.1111/j.1748-1716.1967.tb03736.x.
9
A study on morphological changes and histamine release induced by compound 48/80 in rat peritoneal mast cells.化合物48/80诱导大鼠腹腔肥大细胞形态变化及组胺释放的研究。
Exp Cell Res. 1965 Dec;40(3):637-54. doi: 10.1016/0014-4827(65)90241-7.
10
Increased permeability of the rat mast cell membrane to sodium and potassium caused by extracellular ATP and its relationship to histamine release.细胞外ATP引起大鼠肥大细胞膜对钠和钾的通透性增加及其与组胺释放的关系。
Int Arch Allergy Appl Immunol. 1974;46(5):655-75. doi: 10.1159/000231167.