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肾上腺素能和胆碱能药物对组胺自发释放的调节作用。

Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs.

作者信息

Fantozzi R, Moroni F, Masini E, Blandina P, Mannaioni P F

出版信息

Agents Actions. 1978 Jun;8(4):347-58. doi: 10.1007/BF01968614.

DOI:10.1007/BF01968614
PMID:80107
Abstract

Experiments have been reported on the possible modulation of the spontaneous histamine release by adrenergic and cholinergic drugs. Adrenergic drugs increase the spontaneous histamine release in vivo, and in neoplastic mast cells, in vitro. The mechanism of histamine release appears to be dependent upon the activation of alpha-adrenoceptors. Cholinergic drugs activate the release of histamine in many secretory processes in vivo; in vitro, acetylcholine is one of the most powerful histamine releasers in isolated purified rat mast cells. The release of histamine evoked by acetylcholine in rat mast cells is a calcium-requiring, temperature-dependent exocytosis. The physiological relationship of the sympathetic, parasympathetic and histamine-containing cells are discussed.

摘要

已有关于肾上腺素能和胆碱能药物对组胺自发释放可能调节作用的实验报道。肾上腺素能药物在体内以及体外的肿瘤性肥大细胞中均会增加组胺的自发释放。组胺释放的机制似乎依赖于α-肾上腺素能受体的激活。胆碱能药物在体内的许多分泌过程中可激活组胺的释放；在体外，乙酰胆碱是分离纯化的大鼠肥大细胞中最有效的组胺释放剂之一。乙酰胆碱在大鼠肥大细胞中诱发的组胺释放是一种需要钙且依赖温度的胞吐作用。文中讨论了交感神经、副交感神经与含组胺细胞之间的生理关系。

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Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs.肾上腺素能和胆碱能药物对组胺自发释放的调节作用。
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2
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2
Muscarinic cholinergic receptor binding in rat mast cells.大鼠肥大细胞中的毒蕈碱型胆碱能受体结合
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3
The effects of atropine on anaphylactic shock in the guinea-pig.阿托品对豚鼠过敏性休克的影响。

本文引用的文献

1
The distribution and functional significance of sympathetic vasodilators to the hind limps of the cat.交感舒血管神经对猫后肢的分布及其功能意义
Acta Physiol Scand. 1948 Jul 20;15(4):389-400. doi: 10.1111/j.1748-1716.1948.tb00514.x.
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[Blood histamine determinations after intravenous adrenaline injection for allergic and neuro-vegetative disorders].[静脉注射肾上腺素后对过敏性和神经植物性疾病进行血液组胺测定]
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The interaction of cholinomimetics, peptides and compounds 48/80 on histamine secretion from the mast cell.拟胆碱药、肽类与化合物48/80对肥大细胞组胺分泌的相互作用。
Agents Actions. 1984 Apr;14(3-4):373-5. doi: 10.1007/BF01973831.
7
Mast cell receptors controlling histamine release: influences on the mode of action of drugs used in the treatment of adverse drug reactions.控制组胺释放的肥大细胞受体：对用于治疗药物不良反应的药物作用模式的影响
Klin Wochenschr. 1982 Sep 1;60(17):1031-8. doi: 10.1007/BF01716967.
8
Correlation between cholinergic histamine release and quinuclidinyl-benzilate ([3H]-QNB) binding in mast cell membranes.肥大细胞膜中胆碱能组胺释放与奎宁环基苯甲酸酯（[3H]-QNB）结合之间的相关性。
Agents Actions. 1981 Apr;11(1-2):55-9. doi: 10.1007/BF01991456.
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Inhibition of cholinergic histamine release in rat mast cells.大鼠肥大细胞中胆碱能组胺释放的抑制作用。
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10
Failure of acetylcholine to release histamine from rat mast cells.乙酰胆碱未能从大鼠肥大细胞释放组胺。
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J Physiol. 1927 Aug 8;63(3):201-10. doi: 10.1113/jphysiol.1927.sp002397.
4
The vaso-dilator action of histamine, and its physiological significance.组胺的血管舒张作用及其生理意义。
J Physiol. 1926 Apr 23;61(2):185-214. doi: 10.1113/jphysiol.1926.sp002283.
5
Histamine shock.组胺性休克
J Physiol. 1919 Mar 25;52(5):355-90. doi: 10.1113/jphysiol.1919.sp001837.
6
The physiological action of beta-iminazolylethylamine.β-咪唑基乙胺的生理作用。
J Physiol. 1910 Dec 31;41(5):318-44. doi: 10.1113/jphysiol.1910.sp001406.
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Liberation of histamine by adrenaline from isolated lung.肾上腺素从离体肺中释放组胺。
Arch Int Pharmacodyn Ther. 1950 Jan;81(1):91-8.
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[Liberation of 5-hydroxytryptamine by nicotine].[尼古丁对5-羟色胺的释放作用]
Psychopharmacologia. 1962 Mar 12;3:35-43. doi: 10.1007/BF00413104.
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Cellular mechanisms in anaphylaxis.过敏反应中的细胞机制。
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THE EFFECT OF INDUCED FIBRINOLYSIS AND VARIOUS SUBSTANCES ON THE MAST CELLS IN THE PERITONEAL FLUID AND MESENTERY OF THE RAT.诱导纤维蛋白溶解及各种物质对大鼠腹膜液和肠系膜中肥大细胞的影响。
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