Advenier C, Mallard B, Santais M C, Ruff F
Agents Actions. 1982 Apr;12(1-2):103-7. doi: 10.1007/BF01965117.
The effects of atropine, 2 mg/kg i.v., on anaphylactic shock were studied in guinea-pigs sensitized to ovalbumin. Atropine only moderately reduced (--31%) the increase in pulmonary resistance observed and slightly prolonged (+26%) the survival time in pretreated animals compared with controls. These effects, however, were no statistically significant. The drug temporarily improved ventilation but had no influence on haematosis. On the other hand, atropine significantly reduced the amount of histamine released (--60%) and of GMPc synthetized in the lung (--21%). The levels of AMPc and prostaglandins E1, E2 and F2 alpha remained comparable to those of control animals. These results suggest that the reflex-induced action of the cholinergic system during anaphylaxis primarily affects large-calibre airways and that the role of acetylcholine in severe reactions is moderate when compared with the direct action of other mediators.
研究了静脉注射2mg/kg阿托品对卵清蛋白致敏豚鼠过敏性休克的影响。与对照组相比，阿托品仅适度降低了（-31%）观察到的肺阻力增加，并略微延长了（+26%）预处理动物的存活时间。然而，这些影响无统计学意义。该药物暂时改善了通气，但对血液学无影响。另一方面，阿托品显著降低了组胺释放量（-60%）和肺中合成的GMPc量（-21%）。AMPc和前列腺素E1、E2及F2α的水平与对照动物相当。这些结果表明，过敏反应期间胆碱能系统的反射性作用主要影响大口径气道，并且与其他介质的直接作用相比，乙酰胆碱在严重反应中的作用适中。
