Gómez-Ayala A E, Lisbona F, López-Aliaga I, Barrionuevo M, Pallarés I, Alférez M J, Hartiti S, Campos M S
Departamento de Fisiología, Facultad de Farmacia, Universidad de Granada, Spain.
Exp Physiol. 1994 Jan;79(1):25-33. doi: 10.1113/expphysiol.1994.sp003739.
The effects of time and the type of dietary fat on biliary physiology in rats with 50% resection of the distal small intestine were investigated. The effects of ursodeoxycholic acid as an exogenous source of bile acid added to the diet were also studied. The fat composition of all diets was the same in quantitative terms (4%), and differed only in the type of lipid supplied: olive oil (diet A) or one-third medium chain triglycerides, one-third sunflower seed oil and one-third olive oil (diet B). In resected rats given diet A for 1 or 3 months, there was a decrease in biliary secretion of cholesterol and phospholipids, and in the lithogenic index, with respect to the control group. Resected rats fed diet B for 1 or 3 months showed increases in biliary secretion of cholesterol and phospholipids, and in the lithogenic index, in comparison with resected rats fed diet A. The addition of ursodeoxycholic acid to diet B led to the decoupling of bile acid and bile lipid secretion.
研究了时间和膳食脂肪类型对远端小肠50%切除大鼠胆汁生理的影响。还研究了将熊去氧胆酸作为外源性胆汁酸添加到饮食中的效果。所有饮食的脂肪成分在数量上相同（4%），仅在提供的脂质类型上有所不同：橄榄油（饮食A）或三分之一中链甘油三酯、三分之一向日葵籽油和三分之一橄榄油（饮食B）。与对照组相比，接受饮食A 1个月或3个月的切除大鼠胆汁中胆固醇和磷脂的分泌以及成石指数均降低。与接受饮食A的切除大鼠相比，接受饮食B 1个月或3个月的切除大鼠胆汁中胆固醇和磷脂的分泌以及成石指数均升高。在饮食B中添加熊去氧胆酸导致胆汁酸和胆汁脂质分泌解偶联。
