Coves F, Lisbona F, Campos M S, Garcia J A, Lopez-Aliaga I, Barrionuevo M
Department of Physiology, Faculty of Pharmacy, University of Granada, Spain.
Nahrung. 1991;35(5):503-11. doi: 10.1002/food.19910350515.
The effects of the quality of dietary fat, and the influence of ursodeoxycholic acid, an exogenous bile acid, on the digestive and metabolic utilization of fat were studied in rats in which 50% of the distal small intestine was resected. The fat content of the diets was quantitatively equivalent (4%), and differed only in the type of fat: olive oil (diet A) or 1/3 medium chain triglycerides (MCT), 1/3 sunflower oil and 1/3 olive oil (diet B). The removal of 50% of the distal small intestine led to a highly significant decline in the digestive utilization of fat (ADC) in animals given diet A. Rats fed diet B showed an increase in ADC to values approaching those seen in control animals. The addition of ursodeoxycholic acid to diet B failed to cause a further rise in the ADC of fat. After intestinal resection, serum levels of triglycerides and cholesterol fell more markedly in animals given diet A than in the diet B group, while the addition of ursodeoxycholic acid to diet B led to no further change. Serum lipid levels showed no significant influence of intestinal resection, but did accurately reflect the differences in fat composition between the two types of diet tested.
在切除50%远端小肠的大鼠中，研究了膳食脂肪质量以及外源性胆汁酸熊去氧胆酸对脂肪消化和代谢利用的影响。饮食中的脂肪含量在数量上是相等的（4%），只是脂肪类型不同：橄榄油（饮食A）或1/3中链甘油三酯（MCT）、1/3向日葵油和1/3橄榄油（饮食B）。切除50%远端小肠导致给予饮食A的动物脂肪消化利用率（ADC）显著下降。喂食饮食B的大鼠ADC增加，接近对照组动物的值。在饮食B中添加熊去氧胆酸未能使脂肪的ADC进一步升高。肠道切除后，给予饮食A的动物血清甘油三酯和胆固醇水平下降比饮食B组更明显，而在饮食B中添加熊去氧胆酸未导致进一步变化。血清脂质水平未显示肠道切除的显著影响，但确实准确反映了所测试的两种饮食之间脂肪组成的差异。
