Schmidt-Betschel W, Aust W
Augenklinik des Lehrkrankenhauses Kassel.
Ophthalmologe. 1994 Apr;91(2):198-200.
Morphological alterations of the retina caused by lithium have been described in rats. Human patients were therefore examined for such findings, and photophobia, neuritis affecting the optic nerves and downbeat nystagmus were observed. We found pathologic Arden quotients in the EOG, indicating an alteration of the pigment epithelium. The VEPs showed delayed latencies, whereas the amplitudes remained unchanged. Because of the pathologic electrophysiological findings ophthalmological controls, including EOG and VEP, should be performed yearly in patients taking lithium.
锂对大鼠视网膜造成的形态学改变已有相关描述。因此，对人类患者进行了此类检查，发现畏光、影响视神经的神经炎以及下跳性眼球震颤。我们发现眼电图（EOG）的阿登商数异常，提示色素上皮发生改变。视觉诱发电位（VEP）显示潜伏期延长，而波幅保持不变。鉴于这些病理电生理检查结果，服用锂的患者应每年进行包括EOG和VEP在内的眼科检查。
