[Induction of immune tolerance to protein antigens in mice by 6-mercaptopurine (author's transl)].

The tolerance induction in mice to human serum albumin (HSA) and bovine gamma globulin (BGG) by combined injections of antigen and 6-mercaptopurine is studied. After pretreatment with antigen and mercaptopurine specific unresponsiveness or hyporesponsiveness are observed both in inbred (CBA) and outbred mice. Under the experimental protocol HSA is more tolerogenic than BGG. In CBA-mice tolerance to BGG was only found on the level of IgG-antibodies. The factors which influence the development of a drug-induced immunological unresponsiveness (mice strain, quality of antigen and antigen dosage) and the role of test system are discussed.