6-巯基嘌呤对豚鼠体液免疫反应的影响。1. 抗原和佐剂的重要性（作者译）

[The influence of 6-mercaptopurine on the humoral immune response in guinea pig. 1. The importance of antigen and adjuvans (author's transl)].

作者信息

Kroppe P, Drössler K, Ambrosius H

出版信息

Allerg Immunol (Leipz). 1977;23(1):3-11.

PMID:69395

Abstract

Following an intradermal immunization of guinea pigs with dinitrophenylated bovine gamma globulin (DNP23-BGG), human serum albumin (HSA) and trinitrophenylated sheep red blood cells (TNP-SRBC) emulsified in complete or in incomplete Freund's adjuvans the effectivity of 6-mercaptopurine (6-MP) on the formation of specific antibodies was investigated. By application of 10 mg 6-MP/kf/day--in guinea pigs a significant depression of antibody formation against BGG could be demonstrated if treatment is started on the day of antigen injection and continued for seven days. The production of anti-SRBC agglutinating antibodies was only suppressed if the antigen was injected together with complete Freund's adjuvans. The anti-DNP and anti-HSA antibody formation was not influenced by this kind of immunosuppressive treatment.

摘要

用二硝基苯基化牛γ球蛋白（DNP23 - BGG）、人血清白蛋白（HSA）和三硝基苯基化绵羊红细胞（TNP - SRBC）在完全或不完全弗氏佐剂中乳化后对豚鼠进行皮内免疫，研究了6 - 巯基嘌呤（6 - MP）对特异性抗体形成的有效性。通过每天给豚鼠应用10毫克6 - MP/千克体重，如果在抗原注射当天开始治疗并持续7天，可证明对针对BGG的抗体形成有显著抑制作用。仅当抗原与完全弗氏佐剂一起注射时，抗SRBC凝集抗体的产生才受到抑制。这种免疫抑制治疗不影响抗DNP和抗HSA抗体的形成。

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引用本文的文献

1

The influence of cyclophosphamide and 6-mercaptopurine on the IgG1 and IgG2 immune response in guinea-pigs.环磷酰胺和6-巯基嘌呤对豚鼠IgG1和IgG2免疫反应的影响。

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