Zeichner S L
Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Clin Perinatol. 1994 Mar;21(1):39-73.
In the past 10 years, a large number of investigators have produced an enormous amount of information concerning the molecular biology of HIV. These studies at the most basic biological level have provided essential insights into the pathogenesis of the disease. They have supplied the information necessary for the creation of the antiviral therapies now available and have indicated the direction for the development of new therapies now in clinical trials and under investigation. Although the relatively ineffective therapies currently available serve as a constant source of disappointment for those practitioners who care for HIV-infected patients, there is some comfort to be gained from the rapid pace of investigation into the basic biology of the virus and the certainty that any more effective therapy must build upon the basic biological knowledge already obtained. A detailed study of some of the unique features observed during pediatric and perinatal HIV infection, particularly the relatively shortened time from infection to symptoms and the relative importance of CNS disease, may suggest new therapeutic approaches that will benefit both adult and pediatric patients. Finally, a comprehensive knowledge of HIV biology is an essential requirement for therapeutic maneuvers designed to interrupt the transmission of HIV from mother to child.
在过去十年中，大量研究人员产出了关于HIV分子生物学的海量信息。这些在最基础生物学层面的研究为该疾病的发病机制提供了重要见解。它们为现有抗病毒疗法的研发提供了必要信息，并指明了目前正在临床试验及研究中的新疗法的发展方向。尽管目前可用的相对无效的疗法让那些照料HIV感染患者的从业者不断感到失望，但对该病毒基础生物学的快速研究步伐以及任何更有效疗法都必须基于已获得的基础生物学知识这一确定性，还是能带来一些慰藉。对儿科和围产期HIV感染期间观察到的一些独特特征进行详细研究，尤其是从感染到出现症状的时间相对缩短以及中枢神经系统疾病的相对重要性，可能会提出有利于成人和儿科患者的新治疗方法。最后，全面了解HIV生物学是设计用于阻断HIV母婴传播的治疗策略的一项基本要求。
