甲氧明诱导兔肺动脉释放内源性三磷酸腺苷。
Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery.
作者信息
Takeuchi K, Shinozuka K, Akimoto H, Ishii R, Hashimoto T
机构信息
Department of Pharmacology, Meiji College of Pharmacy, Tokyo, Japan.
出版信息
Eur J Pharmacol. 1994 Mar 21;254(3):287-90. doi: 10.1016/0014-2999(94)90467-7.
Methoxamine, an alpha 1-adrenoceptor agonist, significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery. Among the adenine nucleotides released, the amount of ATP was larger than those of the other two. Such release of adenine nucleotides was not induced by clonidine, an alpha 2-adrenoceptor agonist, and isoproterenol, a beta-adrenoceptor agonist. Methoxamine-induced release was observed in the absence of extracellular calcium, but was not observed at a low temperature, 27 degrees C. This suggests an extracellular calcium-independent and temperature-dependent ATP-releasing mechanism coupled with alpha 1-adrenoceptors in rabbit pulmonary artery.
甲氧明是一种α1肾上腺素能受体激动剂，通过一种对哌唑嗪敏感的机制，显著增加了兔肺动脉中ATP、ADP和AMP的释放，但不增加腺苷的释放。在所释放的腺嘌呤核苷酸中，ATP的量大于其他两种。α2肾上腺素能受体激动剂可乐定和β肾上腺素能受体激动剂异丙肾上腺素未诱导腺嘌呤核苷酸的这种释放。在无细胞外钙的情况下观察到甲氧明诱导的释放，但在27℃的低温下未观察到。这表明兔肺动脉中存在一种与α1肾上腺素能受体偶联的、不依赖细胞外钙且依赖温度的ATP释放机制。
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