Pairon J C, Iwatsubo Y, Hubert C, Lorino H, Nouaigui H, Gharbi R, Brochard P
INSERM Unité 139, Créteil, France.
Eur Respir J. 1994 Mar;7(3):484-9. doi: 10.1183/09031936.94.07030484.
The performance of the forced oscillation technique (FOT) in the assessment of bronchial responsiveness on the methacholine challenge test was compared with that of forced expiratory volume in one second (FEV1) in 119 active workers with normal baseline pulmonary function. Changes in resistance (delta R0%), frequency dependence of resistance (delta P) and resonant frequency (delta F%) determined by the FOT were compared to the delta FEV1%. Receiver operating characteristic (ROC) curves were established to determine values of the changes in FOT parameters which corresponded to the best sensitivity and specificity for classifying the subjects as hyperresponsive or nonresponsive on the methacholine challenge test. Significant correlations were observed between delta FEV1% and delta R0%, delta P and delta F% respectively. The ROC curves showed the following cut-off values of FOT parameters to be the best values for classifying the subjects according to the presence or absence of 20% fall in FEV1: a 65% increase in R0 (sensitivity 75%; specificity: 76%); a decrease of 65 x 10(-3) hPa.l-1.s2 in P (sensitivity 58%; specificity 83%); a 50% increase in F (sensitivity 75%; specificity 62%). Our results suggest that the FOT is a useful test for assessment of bronchial hyperresponsiveness when compared to spirometry, and can be applied to epidemiological studies of a bronchial challenge test in normal active working populations.
在119名基线肺功能正常的在职员工中，对强迫振荡技术（FOT）在乙酰甲胆碱激发试验中评估支气管反应性的表现与一秒用力呼气容积（FEV1）进行了比较。将FOT测定的阻力变化（δR0%）、阻力频率依赖性（δP）和共振频率（δF%）与δFEV1%进行比较。建立受试者工作特征（ROC）曲线，以确定FOT参数变化的值，这些值对应于在乙酰甲胆碱激发试验中将受试者分类为高反应性或无反应性的最佳敏感性和特异性。分别观察到δFEV1%与δR0%、δP和δF%之间存在显著相关性。ROC曲线显示，根据FEV1是否下降20%对受试者进行分类时，FOT参数的以下临界值是最佳值：R0增加65%（敏感性75%；特异性76%）；P下降65×10⁻³hPa·l⁻¹·s²（敏感性58%；特异性83%）；F增加50%（敏感性75%；特异性62%）。我们的结果表明，与肺活量测定法相比，FOT是评估支气管高反应性的一种有用测试，可应用于正常在职人群支气管激发试验的流行病学研究。
