Bhutto A M, Nonaka S, Hashiguchi Y, Gomez E A
Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
J Dermatol. 1994 Mar;21(3):178-84. doi: 10.1111/j.1346-8138.1994.tb01717.x.
Chronic verruga nodules taken from a patient with Bartonellosis (verruga peruana) were studied. Histologically, specimens of all the verruga nodules had features consistent with granulomatous lesions with extensive infiltration of various types of cells along with the proliferation of capillaries. The sections were predominantly infiltrated with neutrophils and endothelial cells; histiocytes, plasma cells, lymphocytes and mast cells were also visible to some extent. The blood vessels were dilated, and many rounded and swollen endothelial cells were located peripherally; a huge number of neutrophils invaded the vessels. Electron microscopically, large number of organisms were seen in different stages of the life cycle in the stroma. Furthermore, organisms were regularly seen either in close contact or existing inside the cytoplasm of neutrophils, suggesting the phagocytic role of these cells. No organism was found inside any endothelial cells or histiocytes.
对取自巴尔通体病（秘鲁疣）患者的慢性疣状结节进行了研究。组织学上，所有疣状结节标本均具有与肉芽肿性病变一致的特征，伴有各种类型细胞的广泛浸润以及毛细血管的增生。切片主要浸润有中性粒细胞和内皮细胞；在一定程度上也可见组织细胞、浆细胞、淋巴细胞和肥大细胞。血管扩张，许多圆形且肿胀的内皮细胞位于周边；大量中性粒细胞侵入血管。电子显微镜下，在基质中可见处于生命周期不同阶段的大量生物体。此外，经常可见生物体与中性粒细胞的细胞质紧密接触或存在于其中，提示这些细胞具有吞噬作用。在内皮细胞或组织细胞内未发现生物体。
