Og4C3循环抗原：班氏吴策线虫丝虫病感染及成虫负荷的标志物
Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis.
作者信息
Chanteau S, Moulia-Pelat J P, Glaziou P, Nguyen N L, Luquiaud P, Plichart C, Martin P M, Cartel J L
机构信息
Institut Territorial de Recherches Médicales Louis Malardé, Papeete, Tahiti, French Polynesia.
出版信息
J Infect Dis. 1994 Jul;170(1):247-50. doi: 10.1093/infdis/170.1.247.
Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.
在94.5%（259/274）的微丝蚴血症患者、32%（239/751）疑似丝虫病患者以及23%（11/48）慢性丝虫病患者的血清中检测到了Og4C3循环丝虫抗原。抗原水平与微丝蚴（Mf）密度及患者年龄相关（P < 0.01）。在用杀微丝蚴药物治疗的患者中，该抗原水平保持稳定。Og4C3抗原在Mf培养基中无法检测到，被证明是一种罕见的Mf体细胞抗原。它似乎是成虫分泌或释放的抗原。它可作为感染标志物及成虫负荷指标。
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