Mercadante S
Department of Anesthesia and Intensive Care, Buccheri La Ferla Hospital, Palermo, Italy.
J Pain Symptom Manage. 1994 Apr;9(3):201-7. doi: 10.1016/0885-3924(94)90131-7.
Fifteen patients with pain due to advanced cancer who no longer obtained relief from conventional treatment using oral or parenteral opioids were administered morphine and bupivacaine by continuous intrathecal infusion. Thirteen patients were implanted at home due to poor medical condition or refusal to be hospitalized. A summary score was derived to monitor the effects of the treatment. Thirteen patients required low doses of intrathecal morphine and bupivacaine and all reported good pain relief until death. Only minor side effects were evidenced. Implantation at home of an intrathecal catheter to administer morphine and bupivacaine provided a degree of pain relief during the last days of life that would have otherwise been impossible and did so without producing important complications.
15例因晚期癌症疼痛且口服或胃肠外使用阿片类药物常规治疗不再有效的患者，通过鞘内持续输注给予吗啡和布比卡因。13例患者因身体状况差或拒绝住院而在家中植入（鞘内导管）。得出一个总结评分以监测治疗效果。13例患者需要低剂量的鞘内吗啡和布比卡因，所有患者均报告直至死亡疼痛得到良好缓解。仅证实有轻微副作用。在家中植入鞘内导管以给予吗啡和布比卡因，在生命的最后几天提供了一定程度的疼痛缓解，否则这是不可能实现的，并且这样做没有产生重大并发症。
