四肢神经鞘瘤：磁共振成像与五价锝-99m-二巯基丁二酸及枸橼酸镓-67闪烁扫描术的比较

Schwannoma of the extremities: comparison of MRI and pentavalent technetium-99m-dimercaptosuccinic acid and gallium-67-citrate scintigraphy.

作者信息

Kobayashi H, Kotoura Y, Sakahara H, Hosono M, Hosono M, Tsaboyama T, Yamamuro T, Endo K, Konishi J

机构信息

Department of Radiology and Nuclear Medicine, Kyoto University, Faculty of Medicine, Japan.

出版信息

J Nucl Med. 1994 Jul;35(7):1174-8.

PMID:8014679

Abstract

The diagnostic value of MRI and scintigraphy was studied in patients with Schwannomas of the upper or lower extremities. MRI (T1- and T2-weighted imaging), pentavalent 99mTc-dimercaptosuccinic acid and 67Ga-citrate scintigraphy were performed in 11 patients with 12 histologically proven benign Schwannomas. All six tumors with a maximum diameter > or = 3 cm showed marked accumulation of pentavalent 99mTc-dimercaptosuccinic acid, whereas they showed no uptake of 67Ga-citrate. MRI detected all of the tumors, and the lesions had a signal intensity equal to or slightly less than that of skeletal muscle on T1-weighted images and hyperintense to that of subcutaneous fat on T2-weighted images. MRI was superior to detect small Schwannomas of the extremities. A positive 99mTc-dimercaptosuccinic acid scan and a negative 67Ga-citrate scan however is useful to distinguish sarcoma with myxoid change from Schwannoma.

摘要

对上下肢神经鞘瘤患者的MRI和闪烁扫描的诊断价值进行了研究。对11例经组织学证实为良性神经鞘瘤的患者进行了MRI（T1加权成像和T2加权成像）、五价99mTc-二巯基丁二酸和67Ga-枸橼酸盐闪烁扫描。所有6个最大直径≥3 cm的肿瘤均显示五价99mTc-二巯基丁二酸明显聚集，而67Ga-枸橼酸盐未摄取。MRI检测到了所有肿瘤，病变在T1加权图像上的信号强度等于或略低于骨骼肌，在T2加权图像上高于皮下脂肪。MRI在检测四肢小神经鞘瘤方面更具优势。然而，99mTc-二巯基丁二酸扫描阳性和67Ga-枸橼酸盐扫描阴性有助于将伴有黏液样改变的肉瘤与神经鞘瘤区分开来。