分剂量碘-123-IMP单光子发射计算机断层扫描：药物干预后局部脑血流量的序贯定量变化
Split dose iodine-123-IMP SPECT: sequential quantitative regional cerebral blood flow change with pharmacological intervention.
作者信息
Hashikawa K, Matsumoto M, Moriwaki H, Oku N, Okazaki Y, Uehara T, Handa N, Kusuoka H, Kamada T, Nishimura T
机构信息
Department of Nuclear Medicine, Osaka University Medical School, Japan.
出版信息
J Nucl Med. 1994 Jul;35(7):1226-33.
UNLABELLED
At least two quantitative rCBF measurements are needed to evaluate rCBF changes with pharmacological intervention. We have developed the split dose 123I-IMP SPECT method, which enables measurement of rCBF to be repeated in a short time.
METHODS
Thirty-one cerebrovascular disease patients were investigated to assess reproducibility and vasoreactivity to acetazolamide. During 44-min dynamic SPECT imaging, 123I-IMP injection and respective arterial sampling were performed twice at an interval of about 25 min. The rCBF values were calculated using a microsphere model in which the washout of 123I-IMP from the brain can be negligible in the first several minutes after injection. For the second rCBF measurement, the remaining activity due to the first 123I-IMP injection was estimated and subtracted from the total brain activity.
RESULTS
In ten patients, two consecutive resting mean rCBF values in the MCA territory (CBF1 and CBF2) had good correlation (CBF1 = 47.4 +/- 4.0 (ml/min/100 ml: mean +/- s.d.), CBF2 = 45.2 +/- 8.2, CBF2 = 0.900*CBF1 + 2.9, r = 0.915). In 11 patients with occlusive lesions in the unilateral ICA system, mean rCBF in the MCA territory was increased by only 27.7% +/- 14.0% in the affected side by a 1-g intravenous acetazolamide injection, while 44.5% +/- 12.3% increase was found in the nonaffected side. In 10 patients without a major arterial lesion, a 49.7% +/- 17.0% increase of rCBF was demonstrated.
CONCLUSIONS
This split dose method 123I-IMP SPECT can be useful to estimate vascular reserve.
未标注
至少需要进行两次定量脑血流量（rCBF）测量，以评估药物干预下的rCBF变化。我们开发了分剂量123I-异碘普胺单光子发射计算机断层扫描（SPECT）方法，该方法能够在短时间内重复测量rCBF。
方法
对31例脑血管疾病患者进行研究，以评估重复性和对乙酰唑胺的血管反应性。在44分钟的动态SPECT成像过程中，123I-异碘普胺注射和相应的动脉采样以约25分钟的间隔进行两次。使用微球模型计算rCBF值，在该模型中，注射后最初几分钟内123I-异碘普胺从脑中的洗脱可忽略不计。对于第二次rCBF测量，估计第一次123I-异碘普胺注射产生的剩余活性，并从全脑活性中减去。
结果
在10例患者中，大脑中动脉（MCA）区域连续两次静息平均rCBF值（CBF1和CBF2）具有良好的相关性（CBF1 = 47.4±4.0（ml/min/100 ml：平均值±标准差），CBF2 = 45.2±8.2，CBF2 = 0.900*CBF1 + 2.9，r = 0.915）。在11例单侧颈内动脉（ICA）系统闭塞性病变患者中，通过静脉注射1克乙酰唑胺，患侧MCA区域的平均rCBF仅增加27.7%±14.0%，而未患侧增加44.5%±12.3%。在10例无主要动脉病变的患者中，rCBF增加了49.7%±17.0%。
结论
这种分剂量123I-异碘普胺SPECT方法可用于评估血管储备。
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