Takahashi N, Ohkubo M, Odano I, Ohtaki H, Noguchi E, Yamazaki Y, Hatano M, Sakai K
Department of Radiology, Niigata University School of Medicine.
Kaku Igaku. 1994 Apr;31(4):319-26.
Regional cerebral blood flow (rCBF) was measured in 13 patients with various cerebral disease by N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT with the microsphere model (rCBF (CbST)), which was compared with 133Xe inhalation SPECT (rCBFXe). Continuous withdrawal of arterial blood was performed for 5 minutes and SPECT image was obtained from 25 min to 55 min after the tracer injection. The reconstructed counts at 5 min was corrected using entire cerebral counts collected at 5 min, 20 min, and 60 min after the tracer injection. As compared with rCBFXe, rCBF (CbST) was underestimated in high flow areas and overestimated in low flow areas. Regional CBF was also measured using one minute short time SPECT images at 5 min (rCBF (Cb5)), 20 min (rCBF (Cb20)), and 60 min (rCBF (Cb60)) after the injection. Regional CBF tended to be underestimated with time from the tracer injection due to the wash-out from brain tissue to blood. In comparison with rCBF (Cb5), rCBF (CbST) was underestimated in high flow areas and overestimated in low flow areas. This error was considered to be due to the correction of reconstruct counts using entire cerebral counts, because of the kinetic behavior of 123I-IMP was different in each region of the brain.
采用微球模型，通过N-异丙基-p-[123I]碘安非他明（IMP）单光子发射计算机断层扫描（SPECT）对13例患有各种脑部疾病的患者进行了局部脑血流量（rCBF）测量（rCBF（CbST）），并与133Xe吸入SPECT（rCBFXe）进行比较。连续抽取动脉血5分钟，并在注射示踪剂后25分钟至55分钟获得SPECT图像。使用示踪剂注射后5分钟、20分钟和60分钟收集的全脑计数对5分钟时的重建计数进行校正。与rCBFXe相比，rCBF（CbST）在高流量区域被低估，在低流量区域被高估。还在注射后5分钟（rCBF（Cb5））、20分钟（rCBF（Cb20））和60分钟（rCBF（Cb60））使用一分钟短时间SPECT图像测量局部脑血流量。由于脑组织向血液的洗脱，从示踪剂注射开始，局部脑血流量随时间有被低估的趋势。与rCBF（Cb5）相比，rCBF（CbST）在高流量区域被低估，在低流量区域被高估。这种误差被认为是由于使用全脑计数对重建计数进行校正，因为123I-IMP在大脑的每个区域的动力学行为不同。
