Scott A B
Smith-Kettlewell Eye Research Institute, San Francisco, Calif. 94115.
J Pediatr Ophthalmol Strabismus. 1994 Mar-Apr;31(2):85-8. doi: 10.3928/0191-3913-19940301-05.
In three monkeys, the right eye was moved from the primary position to a position of 30 degrees to 45 degrees exotropia by suturing the globe to the orbital wall. In two animals perfused immediately following suturing, histological examination showed the medial rectus and its sarcomeres to be lengthened and the lateral rectus and its sarcomeres to be shortened as compared to those of the unoperated control eye. In the third monkey, after exotropia was maintained for 2 months, the muscle lengths changed but the sarcomere lengths were similar to those of the control eye. We interpret this to indicate addition of sarcomeres to the lengthened medial rectus and removal of sarcomeres from the shortened lateral rectus. This adaptation to conform muscle length to eye position may explain the altered eye position which persists following periods of eye deviation due to muscle paralysis, prior surgery, injury, or botulinum toxin treatment.
在三只猴子中，通过将眼球缝合到眶壁，使右眼从初始位置移动到外斜视30度至45度的位置。在缝合后立即灌注的两只动物中，组织学检查显示，与未手术的对照眼相比，内直肌及其肌节变长，外直肌及其肌节变短。在第三只猴子中，外斜视维持2个月后，肌肉长度发生了变化，但肌节长度与对照眼相似。我们认为这表明变长的内直肌增加了肌节，变短的外直肌减少了肌节。这种使肌肉长度适应眼位的适应性变化可能解释了由于肌肉麻痹、先前手术、损伤或肉毒杆菌毒素治疗导致的眼位偏差持续一段时间后仍持续存在的眼位改变。
