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Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism.

作者信息

Morrow J D, Roberts L J

机构信息

Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

出版信息

Methods Enzymol. 1994;233:163-74. doi: 10.1016/s0076-6879(94)33019-0.

DOI:10.1016/s0076-6879(94)33019-0
PMID:8015454
Abstract
摘要

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Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism.前列腺素的质谱分析：由非环氧化酶自由基催化机制产生的F2-异前列腺素。
Methods Enzymol. 1994;233:163-74. doi: 10.1016/s0076-6879(94)33019-0.
2
Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.非环氧化酶衍生的前列腺素（F2-异前列腺素）在磷脂上原位形成。
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Unresolved issues in the analysis of F2-isoprostanes, F4-neuroprostanes, isofurans, neurofurans, and F2-dihomo-isoprostanes in body fluids and tissue using gas chromatography/negative-ion chemical-ionization mass spectrometry.使用气相色谱/负离子化学电离质谱法分析体液和组织中的F2-异前列腺素、F4-神经前列腺素、异呋喃、神经呋喃和F2-二高异前列腺素时存在的未解决问题。
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A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.一系列类前列腺素F2化合物在人体内通过非环氧化酶、自由基催化机制在体内产生。
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Free-radical-generated F2-isoprostane stimulates cell proliferation and endothelin-1 expression on endothelial cells.自由基生成的F2-异前列腺素刺激内皮细胞的细胞增殖和内皮素-1表达。
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Gas chromatography/mass spectrometry and gas chromatography/tandem mass spectrometry of methyl ester/methoxime/trimethylsilyl ether derivatives of prostaglandins.前列腺素甲酯/甲氧肟/三甲基硅醚衍生物的气相色谱/质谱联用及气相色谱/串联质谱分析
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