在一项汇总的横断面研究中，饮食、生活方式、其他参与者特征和氧化平衡评分与血浆 F-类异前列腺素浓度的关联。
Associations of dietary, lifestyle, other participant characteristics, and oxidative balance scores with plasma F-isoprostanes concentrations in a pooled cross-sectional study.
机构信息
Department of Epidemiology, Rollins School of Public Health, Emory University, Mailstop 1518-002-3BB, 1518 Clifton Road NE, Atlanta, GA, 30322, USA.
Winship Cancer Institute, Emory University, Atlanta, GA, USA.
出版信息
Eur J Nutr. 2022 Apr;61(3):1541-1560. doi: 10.1007/s00394-021-02754-2. Epub 2021 Dec 3.
PURPOSE
Plasma F-isoprostanes (FiP) concentration, a reliably measured, valid, systemic oxidative stress biomarker, has been associated with multiple health-related outcomes; however, associations of most individual dietary and lifestyle exposures with FiP are unclear, and there is no reported oxidative balance score (OBS) comprising multiple dietary and/or lifestyle components weighted by their associations with FiP.
METHODS
To investigate cross-sectional associations of dietary and lifestyle characteristics with plasma FiP concentrations, we used multivariable general linear models to compare adjusted mean FiP concentrations across categories of dietary nutrient and whole-food intakes and lifestyle characteristics in two pooled cross-sectional studies (n = 386). We also developed equal-weight and weighted OBS (nutrient- and foods-based dietary OBS, lifestyle OBS, and total OBS), and compared adjusted mean FiP concentrations across OBS tertiles.
RESULTS
Among men and women combined, adjusted mean FiP concentrations were statistically significantly, proportionately 28.1% higher among those who were obese relative to those who were normal weight; among those in the highest relative to the lowest total nutrient intake tertiles, FiP concentrations were statistically significantly lower by 9.8% for carotenes, 13.6% for lutein/zeaxanthin, 10.9% for vitamin C, 12.2% for vitamin E, 11.5% for glucosinolates, and 5% for calcium. Of the various OBS, the weighted OBS that combined total nutrient intakes and lifestyle exposures was most strongly associated with FiP concentrations: among those in the highest relative to the lowest total OBS, mean FiP concentrations were statistically significantly 29.7% lower (P < 0.001).
CONCLUSION
Multiple dietary and lifestyle characteristics, individually, and especially collectively, may contribute to systemic oxidative stress.
目的
血浆 F-同型前列腺素（FiP）浓度是一种可靠测量的、有效的系统氧化应激生物标志物，与多种健康相关结果相关；然而，大多数个体饮食和生活方式暴露与 FiP 的关联尚不清楚，也没有报告包含多个饮食和/或生活方式成分的氧化平衡评分（OBS），这些成分根据它们与 FiP 的关联进行加权。
方法
为了研究饮食和生活方式特征与血浆 FiP 浓度的横断面关联，我们使用多变量线性模型比较了两个汇总横断面研究中（n=386）饮食营养素和全食物摄入量以及生活方式特征类别之间的调整后 FiP 浓度。我们还开发了等权重和加权 OBS（基于营养素和食物的饮食 OBS、生活方式 OBS 和总 OBS），并比较了 OBS 三分位数之间的调整后 FiP 浓度。
结果
在男性和女性中，与体重正常者相比，肥胖者的调整后 FiP 浓度平均高 28.1%；在总营养素摄入量最高和最低三分位数的人群中，类胡萝卜素的 FiP 浓度分别低 9.8%，叶黄素/玉米黄质低 13.6%，维生素 C 低 10.9%，维生素 E 低 12.2%，葡萄糖异硫氰酸盐低 11.5%，钙低 5%。在各种 OBS 中，结合总营养素摄入量和生活方式暴露的加权 OBS 与 FiP 浓度的相关性最强：在最高相对最低总 OBS 的人群中，FiP 浓度平均低 29.7%（P<0.001）。
结论
多种饮食和生活方式特征，单独和尤其综合起来，可能会导致全身氧化应激。
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