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[高压氧疗对下肢糖尿病性血管病变患者微循环、氧平衡及酸碱平衡的影响]

[The effect of hyperbaric oxygenation on the microcirculation, oxygen budget and acid-base equilibrium in patients with diabetic angiopathy of the lower extremities].

作者信息

Gonchar' M G, Vavrik Zh M, Del'tsova E I, Zelenetskiĭ R G

出版信息

Probl Endokrinol (Mosk). 1993 Mar-Apr;39(2):11-3.

PMID:8016041
Abstract

These effects were studied in 52 patients with degrees III-IV diabetic angiopathies of the lower limbs. Microcirculation parameters were found changed in this patient population, this leading to disorders of the oxygen budget and development of metabolic acidosis. Development of destructive changes in the limb evidences failure of the compensatory adaptive mechanisms of microcirculation. Addition of hyperbaric oxygenation to multiple-modality treatment of patients with diabetic angiopathies was conducive to improvement of the blood rheology, of tissue saturation with oxygen, and to essential reduction of metabolic acidosis. The detected microcirculation disorders necessitate addition to the therapeutic complex of the drugs improving the biophysical characteristics of the blood.

摘要

对52例患有III-IV度下肢糖尿病血管病变的患者进行了这些效应的研究。发现该患者群体的微循环参数发生了变化,这导致了氧平衡紊乱和代谢性酸中毒的发展。肢体出现破坏性变化表明微循环的代偿性适应机制失效。在糖尿病血管病变患者的多模式治疗中加入高压氧疗有助于改善血液流变学、组织氧饱和度,并显著降低代谢性酸中毒。检测到的微循环障碍使得有必要在治疗方案中加入改善血液生物物理特性的药物。

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