El-Hawary M F, Ibrahim A M, Eisa A M, Sakr R, Abdel-Khalek M K, El-Basousy M M, Khashaba A A
Gaz Egypt Paediatr Assoc. 1976 Jul-Oct;24(3-4):163-7.
Study of serum and urinary enzyme pattern in nephropathies revealed that before treatment, cases of both acute nephritis and nephrotic syndrome were found to have an increased activity of the three enzymes studied in both serum and urine (Alkaline and acid phosphatases and Lactic dehydrogenase). However, there was no constant correlation between the level of serum and urinary enzyme activities. Distorted pattern of the enzymes has a more protracted course in nephrotics. After treatment, serum and urinary enzymes tended to normalise in cases of acute glomerulonephritis. However, urinary alkaline phosphatase remained high nephrotics after clinical remission. In some cases of acute nephritis, a persistently high level of serum enzyme may indicate an incipient nephrotic element. Nephrotics not responding to the four weeks course of corticosteroid therapy have persistently high serum and urinary enzyme activities. Thus, estimation of serum and urinary enzyme pattern in nephropathies may be of diagnostic and prognostic value.
对肾病患者血清和尿酶模式的研究表明，在治疗前，急性肾炎和肾病综合征患者的血清和尿液中所研究的三种酶（碱性磷酸酶、酸性磷酸酶和乳酸脱氢酶）活性均升高。然而，血清和尿酶活性水平之间并无恒定的相关性。酶模式的改变在肾病患者中病程更为迁延。治疗后，急性肾小球肾炎患者的血清和尿酶趋于正常。然而，肾病患者临床缓解后尿碱性磷酸酶仍保持高水平。在一些急性肾炎病例中，血清酶持续高水平可能提示早期肾病成分。对四周皮质类固醇治疗无反应的肾病患者血清和尿酶活性持续升高。因此，评估肾病患者的血清和尿酶模式可能具有诊断和预后价值。
