Peters F T, Kleibeuker J H
Dept. of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands.
Scand J Gastroenterol Suppl. 1993;200:59-64.
Barrett's oesophagus or columnar epithelium-lined oesophagus is a condition due to chronic gastro-oesophageal reflux. In addition to acid-peptic reflux, reflux of duodenal contents may have a role in its aetiology. The clinical importance of Barrett's oesophagus is the increased risk for development of oesophageal adenocarcinoma. Measures to prevent cancer development have so far been limited to regular screening and early oesophagectomy in the case of severe dysplasia or early cancer. Other modes of intervention, directed toward prevention of dysplasia and possibly regression of Barrett's epithelium, should be sought. Early markers of development toward dysplasia and cancer are necessary if we are to be able to evaluate such measures. Determination of epithelial cell proliferative activity has the potential to be such a marker. A study is now being performed to evaluate the effect of elimination of acid reflux on proliferative activity of Barrett's epithelium in conjunction with the effects of inflammation and development of dysplasia.
巴雷特食管或柱状上皮化生食管是一种由慢性胃食管反流引起的病症。除了酸-消化性反流外，十二指肠内容物反流可能在其病因中起作用。巴雷特食管的临床重要性在于食管腺癌发生风险增加。迄今为止，预防癌症发生的措施仅限于定期筛查以及在严重发育异常或早期癌症情况下进行早期食管切除术。应寻求其他干预方式，以预防发育异常并可能使巴雷特上皮消退。如果我们要能够评估此类措施，发育异常和癌症的早期标志物是必要的。上皮细胞增殖活性的测定有可能成为这样一种标志物。目前正在进行一项研究，以评估消除酸反流对巴雷特上皮增殖活性的影响，以及炎症和发育异常的影响。
